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title: "The seqWell Scope: Focus on UDIs, LP-WGS, Transposase-based technology"
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The seqWell Scope is your source for the latest news in NGS technology. Our 3rd issue is focused on unique dual indexes.

| View in browser A Quarterly Newsletter Information in NGS technology and research September 2022 \| Vol. 01 Issue 3 Greetings there,    I'm excited to share the latest edition of The seqWell Scope!   In this issue we’re taking a deeper dive into purePlex, the latest product in our expanding portfolio of multiplexed NGS library solutions. Our new products team at seqWell created the purePlex™ DNA Library Prep Kit to help address the large and growing number of NGS applications that depend on the sensitivity provided by unique dual indexing (UDI). purePlex builds on seqWell’s core technology for multiplexing and library normalization to provide a new indexing format that expands the number of applications that can be addressed with our unique transposase-based library chemistry.   In the blogs and video links below you’ll have a chance to learn and explore more about how and why UDI indexing matters, and how purePlex was built to use UDIs to solve some of the common needs and workflow challenges associated with implementing UDIs in the lab.   We also take a deeper look at one of the growing areas in NGS: low-pass whole genome sequencing, where multiplexed library prep has an important role to play in allowing sequencing to become a cost-effective method of routine genotyping applications.   October kicks off an exciting stretch for the whole team here at seqWell. We’ll be attending and presenting at a variety of upcoming conferences such as the Tri-Omics Summit (Boston), NERLSCD (Rochester), MWACD (Rochester), Single Cell Genomics (Utrecht), ASHG (Los Angeles) and more. I hope we have a chance to meet in-person at one of these events!   Enjoy the start of autumn!    Best regards, Joseph Mellor, Ph.D. Co-Founder and CSO In this issue: Blog: "When Unique Dual Indexes Matter" (4 minute read) Blog: "Low-Pass Genotyping: Sequencing More with Less" (5 minute read) Video: "purePlex DNA Library Prep System: Speed, Performance, and Auto-Normalization With Unique Dual Indexes" (8 minutes) Product Spotlight: purePlex™ DNA Library Prep Kit (25% off 1st kit thru 9/30) Company News and Upcoming Events: What's new and where to find us next FEATURED BLOGS   When Unique Dual Indexes Matter Choosing the right indexing strategy can mean striking a balance between minimizing your per-sample sequencing costs and selecting the best method for your particular application and sample type. The majority of library prep methods for Illumina sequencing incorporate dual indexing, or labeling both ends of the library molecules with barcodes to enable pooling of many samples into a single flow cell for more economical sequencing. Read the Full Blog Low-Pass Genotyping: Sequencing More with Less Low-pass sequencing, also sometimes called “skim seq” or low-coverage whole genome sequencing (lcWGS) is a widely used method for surveying genomes for >99% of the information they contain, in some cases requiring less than 1x coverage. To understand the capability of this approach, it is helpful to first look at the history of genotyping and how the use of sequencing has changed how we think about surveying genomes. Read the Full Blog FEATURED VIDEO   purePlex DNA Library Prep System:   Speed, Performance, and Auto-Normalization With Unique Dual Indexes Watch the Video PRODUCT SPOTLIGHT   purePlex™ DNA Library Prep Kit: 45-min hands-on time to prepare a multiplex library of 96 samples with 2.5 hrs total elapsed time. Auto-normalization of read counts and insert size over 10-fold input range Unique dual indexes included Connect with our sales team to learn more. COMPANY NEWS AND EVENTS   Register for our next webinar: Enabling Sequencing Applications with Improved Transposase-Based Solutions   Tune in on October 19 to hear an engaging conversation between three seqWellians: Joseph C. Mellor, PhD, co-founder and chief scientific officer; Curtis Knox, director of product management; and Jessica M. Smith, PhD, director of bioinformatics. The trio will explore how transposase-based library technologies are well-suited for a number of challenging high-throughput workflows, and how innovations such as PurePlex, ExpressPlex and Tagify are accelerating critical sequencing-based applications. Register for Webinar Here Check out the latest addition to our website! Our recently released Publications page showcases the various peer-reviewed journals and other accredited outlets that highlight how seqWell technology is revolutionizing next generation sequencing.    We're expanding our team! Do you know someone who is looking to join a company that’s making a positive impact on genomics research with its novel, NGS library prep technology? Send them our way! As we position the company for growth, we’re expanding in all areas including our applications and support team. To learn more about our openings, visit our Careers page.   seqWell is on the move around the globe! Visit our Upcoming Events page to discover opportunities to meet up with us and hear informative presentations.    Please share our newsletter with your colleagues and be sure to follow us on social media. seqWell, 66 Cherry Hill Drive, Beverly, MA Unsubscribe Manage preferences |
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